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External ID FGFR1OP
Ensembl ID ENSG00000112486.4
Start 167322104
End 167363353
1 FGFR1 oncogene partner isoform a; fibroblast growth factor receptor 1 oncogene partner. [Source:RefSeq;Acc:NM_007045]
LocusLink Summary This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified
Genome View in Gbrowse FGFR1OP
Gene with RefSeq(s) Refseq
Locuslink (Gene) 11116

This variant (1) includes an alternate in-frame segment, compared to variant 2. The resulting isoform (a) is lacks an internal segment when compared to isoform b

No antisense detected
Locuslink (Gene) 11116

This variant (2) occurs more frequently than variant 1. It encodes isoform b

No antisense detected
Other cDNA (No refseq) Emblid
Ensemble Mouse ID
External Mouse ID
% identity
ENSMUSG00000023860.2 Fgfr1op 17 80
ENSMUSG00000052031.1 2610315E15Rik 17 88
Cgap gene info 180296  
Top Ten All
Tissue Mormalized expr. Cluster clones : tissue clones
Embryonic Stem cells 20.87 3.388888889
Muscle 12.19 11:90826
Testis 10.28 11:107669
Lymph_Node 7.07 8:113869
Kidney 7.06 8:113979
Bladder 6.16 1:16340
Placenta 4.23 6:142648
Stomach 4.21 3:71656
Lung 3.97 9:227901
mixed 3.84 12:314320
20.87 3.38
12.19 11.00
10.28 11.00
7.07 8.00
7.06 8.00
6.16 1.00
4.23 6.00
4.21 3.00
3.97 9.00
3.84 12.00
Tissue Development Stage Pathology
skeletal muscle adult normal
testis null normal
null null null
lung fetus normal
testis fetus normal
ovary fetus null
ovary adult null
placenta fetus null
placenta adult null
parathyroid fetus null
parathyroid adult null
germinal center null normal
liver null null
kidney null null
stomach null normal
lung null normal
lung 9 weeks normal
lung 12 weeks normal
lung 19 weeks normal
lung 42 weeks normal
lung adult normal
null adult Ewings
heart fetus normal
heart adult normal
uterus fetus normal
uterus adult normal
skin fetus normal
skin adult normal
bone adult enchondroma
null null fibrosarcoma
brain null null
germinal center null null
whole body 9 weeks normal
uterus null leiomyosarcoma
kidney null normal
skin null melanoma
  Ontology Annotation Evidence Source
NM_007045 Biological Process Positive regulation of cell proliferation TAS GOA
NM_194429 Positive regulation of cell proliferation TAS GOA Positive regulation of cell proliferation
antisense ?
Differential Expr.
EST contig